Circadian rhythm regulators

Read with caution! This post was written during early stages of trying to understand a complex scientific problem, and we didn't get everything right. The original author no longer endorses the content of this post. It is being left online for historical reasons, but read at your own risk.

I haven’t had time to look in any detail, but two papers in Nature last month address nuclear receptors involved in regulation of circadian behavior, and one proposes synthetic agonists against these receptors as potential treatment for sleep and metabolic disorders.

http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature11048.html

http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature11030.html

Proposed factors of importance in this mechanism seem to include: BMAL1, REV-ERB-α and REV-ERB-β, PER, and CRY.  I wonder if any of these are misregulated in FFI?